PUBLICATIONS

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Published Manuscripts

Harmon WG, Sleeper LA, Cuniberti L, Messere J, Colan SD, Orav EJ, Towbin JA, Wilkinson JD, Lipshultz SE. Treating Children With Idiopathic Dilated Cardiomyopathy (from the Pediatric, Cardiomyopathy Registry). American Journal of Cardiology 2009; 104:281-286. Full Text (.pdf)

Connuck DM, Sleeper LA, Colan SD, Cox GF, Towbin JA, Lowe AM, Wilkinson JD, Orav EJ, Cuniberti L, Salbert BA, Lipshultz SE. Characteristics and outcomes of cardiomyopathy in children with Duchenne or Becker Muscular Dystrophy: A comparative study from the Pediatric Cardiomyopathy Registry. American Heart J 2008; 155:998-1005. Full Text (.pdf)

Colan SD, Lipshultz SE, Lowe AM, Sleeper LA, Messere J, Cox GF, Lurie PR, Orav EJ, Towbin JA. Epidemiology and cause-specific outcome of hypertrophic cardiomyopathy in children: Findings from the Pediatric Cardiomyopathy Registry. Circulation 2007; 115:773-781. Full Text (.pdf)

Towbin JA, Lowe AM, Sleeper LA, Orav EJ, Clunie S, Messere J, Colan SD, Gox GF, Lurie P, Hsu D, Canter C, Lipshultz SE. Incidence, causes and outcomes of dilated cardiomyopathy in children: Findings from the Pediatric Cardiomyopathy Registry. JAMA 2006; 296(15):1867-1876. Full Text (.pdf)

Cox G, Sleeper L, Lowe A, Towbin J, Colan S, Orav EJ, Lurie P, Messere J, Wilkinson J, Lipshultz SE. Factors associated with establishing a causal diagnosis in children with cardiomyopathy. Pediatrics 2006; 118(4):1519-1531. Full Text (.pdf)

Lipshultz SE. Realizing optimal care for children with cardiovascular disease: Funding challenges and research approaches. Prog Pediatr Cardiol 2005; 20:71-90.

Tsirka AE, Trinkaus K, Chen SC, Lipshultz SE, Towbin JA, Colan SD, Exil V, Strauss AW, Canter CE. Improved outcomes of pediatric dilated cardiomyopathy with utilization of cardiac transplantation. J Am Coll Cardiol 2004; 44:391-7.

Lipshultz SE, Sleeper LA, Towbin JA, Lowe AM, Orav EJ, Cox GF, Lurie PR, McCoy KL, McDonald MA, Messere JE, Colan SD. The incidence of pediatric cardiomyopathy in two regions of the United States. N Engl J Med 2003; 348:1647-55. Full Text (.pdf)

Grenier MA, Osganian SK, Cox GF, Towbin JA, Colan SD, Lurie PR, Sleeper LA, Orav EJ, Lipshultz SE. Design and implementation of the North American Pediatric Cardiomyopathy Registry. Amer Heart J 2000; 139:86-95. Full Text (.pdf)
Lipshultz SE. Ventricular dysfunction clinical research in infants, children and adolescents. Prog Ped Cardiol 2000; 12:1-28.

Marcy L. Schwartz, MD; Gerald F. Cox, MD, PhD; Angela E. Lin, MD; Mark S. Korson, MD; Antonio Perez-Atayde, MD; Ronald V. Lacro, MD; Steven E. Lipshultz, MD. "Clinical Approach to Genetic Cardiomyopathy in Children." Circulation. 1996; 94:2021-2038. Full Text (.pdf)

Pediatric Cardiomyopathy R13 Conference

Published Manuscripts
2007, Volume 23, Issues 1-2 (11 Articles)

Lipshultz SE, Colan SD, Towbin JA, Wilkinson JD. Introduction for "Idiopathic and Primary
Cardiomyopathy in Children". Progress in Pediatric Cardiology. 2007;23(1-2):3.

Colan SD. Classification of the cardiomyopathies. Progress in Pediatric Cardiology. 2007;23(1-2):5-15.

Weintraub RG, Nugent AW, Daubeney PEF. Pediatric cardiomyopathy: The Australian experience. Progress in Pediatric Cardiology. 2007;23(1-2):17-24.

Alvarez JA, Wilkinson JD, Lipshultz SE. Outcome predictors for pediatric dilated cardiomyopathy: A systematic review. Progress in Pediatric Cardiology. 2007;23(1-2):25-32.

Chung WK. Predictive genetic testing for cardiomyopathies. Progress in Pediatric Cardiology. 2007;23(1- 2):33-38.

Kishnani PS, BurnsWechsler S, Li JS. Enzyme-deficiency metabolic cardiomyopathies and the role of enzyme replacement therapy. Progress in Pediatric Cardiology. 2007;23(1-2):39-48.

Rodrigues CO, Shehadeh LA, Webster KA, Bishopric NH. Myocyte deficiency as a target in the treatment of cardiomyopathy. Progress in Pediatric Cardiology. 2007;23(1-2):49-59.

Jefferies JL. Novel medical therapies for pediatric heart failure. Progress in Pediatric Cardiology. 2007;23(1-2):61-66.

Canter CE, Kantor PF. Heart transplant for pediatric cardiomyopathy. Progress in Pediatric Cardiology. 2007;23(1-2):67-72.

Hsu DT. Age-related factors in child heart transplants. Progress in Pediatric Cardiology. 2007;23(1-2):73- 79.

Sokol KC, Armstrong FD, Rosenkranz ER, et al. Ethical issues in children with cardiomyopathy: Making sense of ethical challenges in the clinical setting. Progress in Pediatric Cardiology. 2007;23(1-2):81-87.

2007, Volume 24, Issue 1 (13 Articles)

Lipshultz SE, Colan SD, Towbin JA, Wilkinson JD. Idiopathic and primary cardiomyopathies in children. Progress in Pediatric Cardiology. 2007;24(1):1.

Mestroni L, Miyamoto SD, Taylor MRG. Genetics of dilated cardiomyopathy conduction disease.
Progress in Pediatric Cardiology. 2007;24(1):3-13.

Cox GF. Diagnostic approaches to pediatric cardiomyopathy of metabolic genetic etiologies and their relation to therapy. Progress in Pediatric Cardiology. 2007;24(1):15-25.

Sheikh F, Chen J. Mouse models for cardiomyopathy research. Progress in Pediatric Cardiology. 2007;24(1):27-34.

Dellefave LM, McNally EM. Cardiomyopathy in neuromuscular disorders. Progress in Pediatric
Cardiology. 2007;24(1):35-46.

Cooper Jr LT. Giant cell myocarditis in children. Progress in Pediatric Cardiology. 2007;24(1):47-49.

Kaufman BD, Shaddy RE. Beta-adrenergic receptor blockade and pediatric dilated cardiomyopathy. Progress in Pediatric Cardiology. 2007;24(1):51-57.

Miller TL, Neri D, Extein J, Somarriba G, Strickman-Stein N. Nutrition in pediatric cardiomyopathy. Progress in Pediatric Cardiology. 2007;24(1):59-71.

Expanded Abstracts from Young Investigators

Alcalai R, Arad M, Depreux F, Wang L, Seidman JG, Seidman CE. Hypertrophy, electrical abnormalities, autophagic vacuoles accumulation and cardiac fibrosis in LAMP2 cardiomyopathy mouse model. Progress in Pediatric Cardiology. 2007;24(1):73-74.

Joshi VA, Roberts AE, Kucherlapati RS. Noonan syndrome associated congenital hypertrophic
cardiomyopathy and the role of sarcomere gene mutations. Progress in Pediatric Cardiology.
2007;24(1):75-76.

Rossano JW, Dreyer WJ, Kim JJ, et al. Pre-transplant serum creatinine predicts long-term outcome in pediatric heart transplant patients. Progress in Pediatric Cardiology. 2007;24(1):77-78.

Taylor MRG. When echocardiogram screening "is not enough". Progress in Pediatric Cardiology. 2007;24(1):79-80.

Ratnasamy C, Kinnamon DD, Lipshultz SE, Rusconi PG. Associations between neurohormonal and inflammatory activation and heart failure in children. Progress in Pediatric Cardiology. 2007;24(1):81-82.

Volume 25, Issue 1, April 2008 - Expert Round Tables for Future Direction in Pediatric CardiomyopathyResearch

Towbin JA. Molecular Mechanisms of Pediatric Cardiomyopathies and New Targeted Therapies Progress in Pediatric Cardiology 2008; 25(3):3-21

Lipshultz SE, Wilkinson JD. Epidemiological and Outcomes Research in Children with Pediatric
Cardiomyopathy Progress in Pediatric Cardiology 2008; 25(3):23-25.

Colan SD. Clinical Issues in the Pediatric Hypertrophic Cardiomyopathies Progress in Pediatric
Cardiology 2008; 25(3):27-29.

Wilkinson JD, Sleeper LA, Alvarez JA, Bublik N, Lipshultz SE. The Pediatric Cardiomyopathy Registry: 1995-2007 Progress in Pediatric Cardiology 2008; 25(3):31-36.

Young K. Hare JM. Stem Cells in Cardiopulmonary Development: Implications for novel approaches to therapy for Pediatric Cardiopulmonary Disease Progress in Pediatric Cardiology 2008; 25(3):37-49.

Negro A, Dodge-Kafka K, Kapiloff MS. Signalosomes as Therapeutic Targets Progress in Pediatric Cardiology 2008; 25(3):51-56.

Menon SC, Olson TM, Michels V. Genetics of Familial Dilated Cardiomyopathy Progress in Pediatric Cardiology 2008; 25(3):57-67.

Hill KD, Rizwan H, Exil VJ. Pediatric Cardiomyopathies Related to Fatty Acid Metabolism Progress in Pediatric Cardiology 2008; 25(3):69-78.

Fisher SD, Pearson GD. Peripartum Cardiomyopathy: An Update Progress in Pediatric Cardiology 2008; 25(3):79-84.

Webber SA. Primary Restrictive Cardiomyopathy in Childhood Progress in Pediatric Cardiology 2008; 25(3):85-90

Somarriba G, Extein J, Miller TL. Exercise Rehabilitation in Pediatric Cardiomyopathy Progress in Pediatric Cardiology 2008; 25(3):91-102

Bublik N, Alvarez JA, Lipshultz SE. Pediatric Cardiomyopathy as a Chronic Disease: A Look at Comprehensive Care Programs Progress in Pediatric Cardiology 2008; 25(3):103-111

Published Abstracts

Jefferies JL, Colan SD, Sleeper LS, Towbin JA, Pahl E, Kantor PF, Everitt MD, Webber SA, Kaufman BD, Lamour JM, Canter CE, Hsu DT, Addonizio L, Lipshultz SE. Outcome and Risk Stratification for Children with Left Ventricular Noncompaction: Findings from the Pediatric Cardiomyopathy Registry. Circulation, Nov 2009; 120: S794.

Miller TL, Orav EJ, Wilkinson JD, Sleeper LA, Towbin JA, Colan SD, Hsu DT, Canter CE, Webber SA, Lipshultz SE. Nutritional Status is Associated with Cardiac Outcomes and Mortality in Children with Idiopathic Dilated Cardiomyopathy. Circulation, Nov 2009; 120: S861.

Pahl E, Canter CE, Colan SD, Lu M, Webber SA, Sleeper LS, Jefferies JL, Hsu DT, Everitt MD, Kantor P, Kaufman BD, Wilkinson JD, Towbin JE, Lipshultz SE. Sudden Death in 1803 Children with Dilated Cardiomyopathy: Rates and Risk Factors. Circulation, Nov 2009; 120: S738.

Webber S, Lipshultz SE, Sleeper LA, Wilkinson JD, Addonizio LJ, Canter CE, Everitt MD, Kantor P, Lamour JM, Lu M, Margossian R, Pahl E, Rusconi P, Colan SD, Towbin JA. Phenotypic Heterogeneity and Outcomes of Restrictive Cardiomyopathy in Childhood - A Report from the NHLBI Pediatric Cardiomyopathy Registry. Circulation Supplement 2008; 118: 6071.

Lipshultz SE, Orav EJ, Wilkinson JD, Towbin JA, Messere J, Lowe AM, Sleeper LA, Clunie SK, Cox GF, Lurie PR, Hsu DT, Canter CE, Colan SD. A Risk Stratification Analysis of Predictors of Death or Transplant in Children with Hypertrophic Cardiomyopathy. Circulation Supplement 2008; 118: 4956.

Singh TP, Sleeper LA, Lipshultz S, Cinar A, Canter C, Webber SA, Bernstein D, Pahl E, Alvarez J, Towbin JA, Colan SA. Association of left ventricular dilation at listing for heart transplant with post-listing and early post-transplant survival in pediatric dilated cardiomyopathy. J Heart Lung Transplant 2008; 27:S255.

Pietra BA, Kantor PF, Bartlett HL, Chin C, Canter CE, Larsen RL, Edens E, Colan SD, Towbin JA, Lipshultz SE, Kirklin JK, Naftel DC, Hsu DT. Clinical factors associated with UNOS status and outcome after listing for heart transplant in children with dilated cardiomyopathy. Circulation Supplement 2007; 116: II-565.

Wilkinson JD, Lowe AM, Salbert BA, Sleeper LA, Towbin JA, Colan SD, Cox GF, Connuck DM, Cadregari E, Clunie SK, Messere J, Lipshultz SE. Outcomes in children with Noonan Syndrome and Cardiomyopathy. Circulation Supplement 2007; 116: II-513.

Foerster S, Canter C, Carey A, Sleeper LA, Jefferies JL, Kantor P, Lamour J, Margossian R, Messere J, Pahl E, Rusconi P, Shaddy R, Webber S, Towbin J, Lipshultz S. A comparative analysis of outcomes for pediatric patients with biopsy-proven Myocarditis, clinically-diagnosed Myocarditis and idiopathic dilated cardiomyopathy. Circulation Supplement 2007; 116: II-565.

Jeffrey A. Towbin, April M. Lowe, Steven D. Colan, Lynn A. Sleeper, E. John Orav, Sarah Clunie, Jane Messere, Gerald Cox, Paul R. Lurie, Daphne Hsu, Charles Canter, James D. Wilkinson, Steven E. Lipshultz, "Incidence, Causes, and Outcomes of Dilated Cardiomyopathy in Children". JAMA Vol 296, No. 15, 1867-1876. Full Text (.pdf)

Gerald F. Cox, Lynn A. Sleeper, April M. Lowe, Jeffrey A. Towbin, Steven D. Colan, E. John Orav, Paul R. Lurie, Jane E. Messere, James D. Wilkinson and Steven E. Lipshultz, "Factors Associated With Establishing a Causal Diagnosis for Children With Cardiomyopathy". Pediatrics 118: No 4, October 2006. Full Text (.pdf)

Colan SD, Lowe AM, Lipshultz SE, Sleeper LA, Cox GF, Lurie PR, Towbin JA. Etiology-specific outcome in pediatric hypertrophic cardiomyopathy. Circulation Supplement 2004; 110: III-516. Full Text (.pdf) Presentation (.ppt)

Lipshultz SE, Orav EJ, Towbin JA, Messere J, Iadarola S, Cuniberti L, Lowe AM, Clunie S, Cox GF, Lurie PR, Canter C, Hsu D, Morrow WR, Colan SD. Outcome predictors in pediatric hypertrophic cardiomyopathy. Circulation Supplement 2004; 110: III-442. Full Text (.pdf) Presentation (.ppt)

Sleeper LA, Towbin JA, Colan, SD, Hsu DT, Lemler M, Messere J, Clunie S, Cuniberti L, Servedio D, Rodgers-Augustyniak L, Lowe AM, Iadarola S, Orav EJ, Lipshultz SE, "Impaired Functional Status In Children With Cardiomyopathy: A Report From The Pediatric Cardiomyopathy Registry". Circulation Supplement 110: III-385, 2004. Full Text (.pdf) Poster (.ppt)

Harmon W, Sleeper LA, Cuniberti L, Messere J, Colan SD, Orav EJ, Towbin JA, Lipshultz SE. Dilated cardiomyopathy: An analysis of therapy offered to children enrolled in the pediatric cardiomyopathy registry. Proc CHOP Ped Cardiol Program (2004).

Connuck D, Sleeper L, Towbin J, Colan S, Cox G, Cuniberti L, Orav EJ, Salbert BA, Lipshultz SE. Characteristics of Duchenne and Becker muscular dystrophy patients in the Pediatric Cardiomyopathy Registry. J Am Coll Cardiol Supplement 43:1164-126, 2004. Full Text (.pdf)

Cox G, Sleeper L, Lowe A, Orav EJ, Colan SD, Towbin JA, Messere J, Lipshultz SE. Variables associated with a known etiology of cardiomyopathy in children: A retrospective analysis of the pediatric cardiomyopathy registry (PCMR) from 1990-1995. Circulation 2001; 104:II-588. Full Text (.pdf)

Lipshultz SE, Sleeper LA, Towbin JA, Lowe AM, Orav EJ, Cox G, Lurie PR, McCoy KL, Messere JE, Orfaly RA, Colan SD. The incidence of pediatric cardiomyopathy: The prospective Pediatric Cardiomyopathy Registry. J Am Coll Cardiol Supplement 2001; 37:1180-196. Full Text (.pdf)

Orfaly R, Nash P, Sleeper L, McCoy K, Lipshultz S. Converting centralized data entry to web-based data entry also means changing habits.” Control Clin Trials Supplement 2001; 22:48.

Lipshultz SE, Grenier MA, Colan SD, Kleinman K, Osganian V, Lurie PR, Cox G, Towbin JA. The incidence of pediatric cardiomyopathy in the NHLBI pediatric cardiomyopathy registry. Pediatr Res 1999; 45:26A.

Lipshultz SE, Towbin JA, Grenier MA, Osganian V, Colan SD, Kleinman K, Sleeper L, Shaddy R, Cox G, Lurie P. Etiology and family history of pediatric cardiomyopathy: The early Pediatric Cardiomyopathy Registry (PCMR) experience. Pediatric Research 1998; 43:24A.

Lipshultz SE, Towbin JA, Grenier MA, Osganian V, Colan SD, Sleeper L, Shaddy R, Cox GF, Lurie P. Etiology and family history of pediatric cardiomyopathy: The early Pediatric Cardiomyopathy Registry (PCMR) experience. J Amer Coll Cardiol Supplement 1998; 31:30A(1014-158).

Other PCMR Presentations

Sleeper LA, Towbin JA, Colan SD, Hsu DT, Wilkinson JD, Miller TL, Lipshultz, SE. Functional Status is Impaired and Correlated with Clinical Status in Pediatric Cardiomyopathy. Presented at the 5th World Congress of Paediatric Cardiology and Cardiac Surgery (PCCS 2009 - Australia).

Cox GF, Colan SD, Sleeper LA, Towbin JA, Kantor P, Wilkinson JD, Lipshultz SE. Mitochondrial Disorders: Characteristics and Outcome from the Pediatric Cardiomyopathy Registry. Presented at the 5th World Congress of Paediatric Cardiology and Cardiac Surgery (PCCS 2009 - Australia).

Wilkinson J, Lowe A, Salbert B, Sleeper L, Towbin J, Colan S, Cox G, Connuck D, Cadregari E, Clunie S, Lipshultz S. Outcomes in children with Noonan Syndrome and cardiomyopathy. Poster presentation at the NIH and Rare Diseases Clinical Research Network, “Clinical Research for Rare Diseases: Opportunities, Challenges, and Solutions”, September 5, 2007.

Alvarez J, Wilkinson J, Lipshultz S. Outcome predictors for pediatric dilated cardiomyopathy: A systematic review. Poster presentation at the NIH and Rare Diseases Clinical Research Network, “Clinical Research for Rare Diseases: Opportunities, Challenges, and Solutions”, September 5, 2007.

Connuck D, Sleeper L, Towbin J, Colan S, Cox G, Lowe A, Orav J, Messere J, Salbert BA, Lipshultz S. Characteristics of DMD/BMD patients at enrollment in the PCMR. Oral Presentation, 2003 Muscular Dystrophy Association Special Meeting on Cardiomyopathy in Patients with Muscular Dystrophies.

Harmon WG, Sleeper LA, Cuniberti L, Messere J, Colan SD, Orav EJ, Towbin JA, and Lipshultz SE. "Dilated Cardiomyopathy: An Analysis Of Therapy Offered to Children Enrolled in the Pediatric Cardiomyopathy Registry." Poster presentation at Cardiology 2004, Children's Hospital of Philadelphia sponsored Annual Conference, Orlando, Florida, February 25, 2004. Full Text (.pdf)

Harmon WG, Sleeper LA, Cuniberti L, Messere J, Colan SD, Orav EJ, Towbin JA, and Lipshultz SE. "Dilated Cardiomyopathy: An Analysis of Therapy Offered to Children Enrolled in the Pediatric Cardiomyopathy Registry." Platform presentation at the Pediatric Academy of Sciences/Society for Pediatric Research, San Francisco, CA, May 4, 2004.

Salbert BA, Lowe AM, Connuck DM, Towbin JA, Colan SD, Cox GF, Sleeper LA, Cadregari ER, Clunie SC, Messere J, Lipshultz SE. Noonan Syndrome and cardiomyopathy: outcome indicators. Poster presentation at American Society for Human Genetics Annual Meeting, Los Angeles, CA, November 25, 2003. Full Text (.pdf)

Grand rounds and invited local talks not shown in this summary.